반응 #162784

반응 방정식

Triisopropylsilylchloride

3-(5-amino-3-tert-butyl-pyrazol-1-yl)-phenol

imidazole

→

title compound

수율 99.7%

5-tert-Butyl-2-(3-triisopropylsilanyloxy-phenyl)-2H-pyrazol-3-ylamine

수율 99.7%

용매

DMF

반응 조건

후처리

1. 1
   기타then partitioned between EtOAc and water
2. 2
   추출The aqueous layer was then extracted with EtOAc (3×)
3. 3
   세척The combined organic layers were washed with brine
4. 4
   건조dried (MgSO4)
5. 5
   여과filtered
6. 6
   기타evaporated in vacuo
7. 7
   기타The residue was purified by FCC

실험 절차

Triisopropylsilylchloride (1.02 mL, 3.96 mmol) was added to a solution of 3-(5-amino-3-tert-butyl-pyrazol-1-yl)-phenol (915 mg, 3.96 mmol) and imidazole (646 mg, 9.50 mmol) in DMF (15 mL) at 0° C. The reaction was stirred at RT over the weekend then partitioned between EtOAc and water. The aqueous layer was then extracted with EtOAc (3×). The combined organic layers were washed with brine, dried (MgSO4), filtered and evaporated in vacuo. The residue was purified by FCC, using 0-40% EtOAc in cyclohexane, to give the title compound (1.53 g, 99%). LCMS (Method 4): Rt 4.78 min, m/z 388 [MH+].

출처