반응 #162063

반응 방정식

propane-1-sulfonyl chloride

N-(azetidin-3-yl)-2-(5-chloro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrimidin-4-amine hydrochloride

6c

N-(azetidin-3-yl)-2-(5-chloro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrimidin-4-amine hydrochloride

Morpholine

iPr2NEt

→

desired product

수율 43.0%

2-(5-chloro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoro-N-(1-(propylsulfonyl)azetidin-3-yl)pyrimidin-4-amine

수율 43.0%

용매

THF

반응 조건

후처리

1. 1
   기타reaction
2. 2
   기타the solution evaporated to dryness
3. 3
   workup.DISSOLUTIONThe resulting residue was dissolved in methanol (2 mL)
4. 4
   workup.ADDITIONthen treated with 25% sodium methoxide/methanol (0.5 mL)
5. 5
   온도heated at 60° C. in sealed tube for 10 minutes
6. 6
   기타The resulting solution was quenched with aqueous saturated NH4Cl solution (0.5 mL)
7. 7
   기타then evaporated to dryness
8. 8
   workup.DISSOLUTIONThe resulting residue was dissolved in DMSO
9. 9
   기타purified by reverse phase HPLC (ammonium formate buffer)

실험 절차

To a stirred suspension of N-(azetidin-3-yl)-2-(5-chloro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrimidin-4-amine hydrochloride, 6c, (0.055 g, 0.110 mmol) in THF (1 mL) was added iPr2NEt (0.300 mL, 1.720 mmol) followed by propane-1-sulfonyl chloride (0.012 mL, 0.108 mmol). The resulting homogenous light yellow solution mixture was heated at 50° C. for one hour at which time LCMS showed complete reaction. Morpholine (0.20 mL) was added and the solution evaporated to dryness. The resulting residue was dissolved in methanol (2 mL) then treated with 25% sodium methoxide/methanol (0.5 mL) and heated at 60° C. in sealed tube for 10 minutes. The resulting solution was quenched with aqueous saturated NH4Cl solution (0.5 mL) then evaporated to dryness. The resulting residue was dissolved in DMSO and purified by reverse phase HPLC (ammonium formate buffer) to afford 19.8 mg (43% yield) of the desired product, 423, as a solid.

출처