반응 #161861

반응 방정식

tetrabutylammonium fluoride

water

3-trimethylsilanyl-prop-2-yn-1-ol

1-[2′-(5-fluoro-2,3-dihydro-indole-1-carbonyl)-5′-iodo-3,4,5,6-tetrahydro-2H-[1,4′]bipyridinyl-4-yl]-1,3-dihydro-imidazo[4,5-b]pyridin-2-one

→

1-[2′-(5-fluoro-2,3-dihydro-indole-1-carbonyl)-5′-(3-hydroxy-prop-1-ynyl)-3,4,5,6-tetrahydro-2H-[1,4′]bipyridinyl-4-yl]-1,3-dihydro-imidazo[4,5-b]pyridin-2-one

용매

THF

1,4-dioxane

반응 조건

후처리

1. 1
   기타the precipitate formed
2. 2
   여과filtered
3. 3
   workup.STIRRINGThe precipitate was stirred in 6 mL DMF
4. 4
   여과suction filtered
5. 5
   기타The filtrate was purified by preparative HPLC-MS
6. 6
   기타freeze-dried

실험 절차

Under an argon atmosphere 44 mg (0.34 mmol) 3-trimethylsilanyl-prop-2-yn-1-ol, 50 μL TEA, 13 mg 1,1′-bis(diphenylphosphine)ferrocene dichloropalladium (II) and 3 mg (20 μmol) copper(I) iodide were added to 0.10 g (0.17 mmol) 1-[2′-(5-fluoro-2,3-dihydro-indole-1-carbonyl)-5′-iodo-3,4,5,6-tetrahydro-2H-[1,4′]bipyridinyl-4-yl]-1,3-dihydro-imidazo[4,5-b]pyridin-2-one in 4.0 mL 1,4-dioxane. Then 0.36 mL (0.36 mmol) of a 1 molar tetrabutylammonium fluoride solution in THF were added dropwise and the mixture was then stirred for 4 h at 80° C. The reaction mixture was mixed with water and the precipitate formed was suction filtered. The precipitate was stirred in 6 mL DMF and suction filtered. The filtrate was purified by preparative HPLC-MS. The product-containing fractions were combined and freeze-dried.

출처