반응 #1617

반응 방정식

Lithium aluminium hydride

5-Benzyloxy-2-hydroxy benzoic acid methyl ester

→

4-benzyloxy-2-hydroxymethyl phenol

용매

tetrahydrofuran

tetrahydrofuran

반응 조건

후처리

1. 1
   온도The mixture was warmed to room temperature
2. 2
   온도The reaction was then cooled to 0° C.
3. 3
   기타cautiously quenched by the addition of water (0.5 ml), 2M sodium hydroxide solution (0.5 ml), and water (1 ml)
4. 4
   workup.STIRRINGThe resulting mixture was stirred at room temperature for 30 minutes
5. 5
   여과filtered
6. 6
   기타The filtrate was evaporated in vacuo

실험 절차

Lithium aluminium hydride (0.235 g, 6.2 mMol) was suspended in tetrahydrofuran (25 ml) and cooled to 0° C. 5-Benzyloxy-2-hydroxy benzoic acid methyl ester (2 g, 7.75 mMol) in tetrahydrofuran (10 ml) was added dropwise, via cannula. The mixture was warmed to room temperature and stirred for 20 minutes. The reaction was then cooled to 0° C. and cautiously quenched by the addition of water (0.5 ml), 2M sodium hydroxide solution (0.5 ml), and water (1 ml). The resulting mixture was stirred at room temperature for 30 minutes and filtered. The filtrate was evaporated in vacuo to yield 4-benzyloxy-2-hydroxymethyl phenol as a clear oil which was used in the next step without further purification.

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