반응 #161687

반응 방정식

water

1-piperidin-4-yl-1,3-dihydro-imidazo[4,5-b]pyridin-2-one dihydrochloride

DIPEA

ethyl 6-chloropyrimidine-4-carboxylate

→

ethyl 6-[4-(2-oxo-2,3-dihydro-imidazo[4,5-b]pyridin-1-yl)-piperidin-1-yl]-pyrimidine-4-carboxylate

용매

ethyl acetate

DMF

반응 조건

후처리

1. 1
   workup.STIRRINGstirred for 10 min
2. 2
   workup.STIRRINGthe mixture was stirred vigorously
3. 3
   여과filtered
4. 4
   기타dried at 40° C. in the circulating air dryer

실험 절차

5.40 g (18.6 mmol) 1-piperidin-4-yl-1,3-dihydro-imidazo[4,5-b]pyridin-2-one dihydrochloride and 11 mL (63.93 mmol) DIPEA were added to 3.40 g (18.2 mmol) ethyl 6-chloropyrimidine-4-carboxylate in 80 mL DMF. After 3 h stirring at RT the solvent was eliminated i.vac. The residue was combined with 70 mL water and stirred for 10 min. 5 mL ethyl acetate were added and the mixture was stirred vigorously. The precipitated solid was suction filtered and dried at 40° C. in the circulating air dryer.

출처