반응 #161684

반응 방정식

3-piperidin-4-yl-1,3,4,5-tetrahydro-1,3-benzodiazepin-2-one

DIPEA

ethyl 6-chloropyrimidine-4-carboxylate

→

ethyl 6-[4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidin-1-yl]-pyrimidine-4-carboxylate

용매

DMF

water

반응 조건

후처리

1. 1
   workup.STIRRINGstirred for 30 min
2. 2
   여과filtered
3. 3
   세척washed with water
4. 4
   기타dried at 50° C. in the CAD

실험 절차

700 mg (2.85 mmol) 3-piperidin-4-yl-1,3,4,5-tetrahydro-1,3-benzodiazepin-2-one and 470 μL (2.73 mmol) DIPEA were added to 500 mg (2.68 mmol) ethyl 6-chloropyrimidine-4-carboxylate in 10 mL DMF and the reaction mixture was stirred for 1 h at RT. The reaction mixture was diluted with water and stirred for 30 min. The precipitate was suction filtered, washed with water and dried at 50° C. in the CAD.

출처