반응 #161494

반응 방정식

water

potassium carbonate

2-(methylthio)ethylamine

2-(4-fluoro-3-nitrophenyl)benzoxazole

→

title compound

수율 98.0%

N-(2-(methylthio)ethyl)-4-(benzoxazol-2-yl)-2-nitroaniline

수율 98.0%

용매

acetonitrile

반응 조건

후처리

1. 1
   온도this was heated
2. 2
   온도to reflux for 3 hours
3. 3
   여과after the precipitated crystals were filtered
4. 4
   세척washed with water, they
5. 5
   기타were dried

실험 절차

To a suspension of 2-(4-fluoro-3-nitrophenyl)benzoxazole (see Working Example 15-2) (300 mg, 1.16 mmol) in acetonitrile (5 mL) was added potassium carbonate (321 mg, 1.55 mmol) and 2-(methylthio)ethylamine (127 mg, 1.39 mmol), and this was heated to reflux for 3 hours. After the reaction was complete, this was cooled to room temperature, water was added, and after the precipitated crystals were filtered and washed with water, they were dried to yield the title compound (373 mg, 98% yield) as red crystals.

출처