반응 #1614

반응 방정식

2-benzyloxyphenol

potassium carbonate

(S)-Glycidyl-3-nitrobenzenesulphonate

→

title compound

(S)-Glycidyl-2-benzyloxyphenol

용매

acetone

반응 조건

후처리

1. 1
   온도was heated
2. 2
   온도under reflux for 15 mins
3. 3
   온도the reaction mixture was heated
4. 4
   온도under reflux for 23 hours
5. 5
   온도After cooling
6. 6
   여과the reaction mixture was filtered
7. 7
   기타the solvent was evaporated
8. 8
   기타The residue was partitioned between ethyl acetate and water
9. 9
   세척washed with water and brine
10. 10
    기타dried
11. 11
    기타evaporated

실험 절차

A mixture of 2-benzyloxyphenol (900 mg, 4.5 mMol) and potassium carbonate (1.87 g, 13.5 mMol) in acetone (45 ml) was heated under reflux for 15 mins. (S)-Glycidyl-3-nitrobenzenesulphonate (1.0 g, 4.5 mMol) was added and the reaction mixture was heated under reflux for 23 hours. After cooling, the reaction mixture was filtered and the solvent was evaporated. The residue was partitioned between ethyl acetate and water. The organic fractions were combined, washed with water and brine, dried and evaporated to give the title compound as an oil.

출처