반응 #161266

반응 방정식

NaOH

ethyl 2-(4-aminophenyl)-2-methylpropanoate

LiAlH4

→

2-(4-aminophenyl)-2-methylpropan-1-ol

용매

THF

반응 조건

후처리

1. 1
   추출extracted with EtOAc
2. 2
   건조the organic layers were dried over Na2SO4
3. 3
   기타The solvent was removed under reduced pressure

실험 절차

A solution of ethyl 2-(4-aminophenyl)-2-methylpropanoate (30 mg, 0.145 mmol) in THF (1 mL) was treated with LiAlH4 (1M solution in THF, 0.226 mL, 0.226 mmol) at 0° C. and stirred for 15 min. The reaction was treated with 0.1N NaOH, extracted with EtOAc and the organic layers were dried over Na2SO4. The solvent was removed under reduced pressure to yield 2-(4-aminophenyl)-2-methylpropan-1-ol (G-2), which was used withoutfurther purification: 1H NMR (400 MHz, CDCl3) δ 7.17 (d, J=8.5 Hz, 2H), 6.67 (d, J=8.5 Hz, 2H), 3.53 (s, 2H), 1.28 (s, 6H).

출처