반응 #161192

반응 방정식

2-tert-butyl-4-bromo-5-nitrophenol

→

2-tert-butyl-4-bromo-5-amino-phenol

수율 70.0%

용매

MeOH

반응 조건

후처리

1. 1
   여과The mixture was filtered
2. 2
   농축the filtrate was concentrated
3. 3
   기타The crude product was recrystallized from ethyl acetate and petroleum ether

실험 절차

To a solution of 2-tert-butyl-4-bromo-5-nitrophenol (C-14-a) (12 g, 43.8 mmol) in MeOH (90 mL) was added Ni (2.4 g). The reaction mixture was stirred under H2 (1 atm) for 4 h. The mixture was filtered and the filtrate was concentrated. The crude product was recrystallized from ethyl acetate and petroleum ether to give 2-tert-butyl-4-bromo-5-amino-phenol (C-27) (7.2 g, 70%). 1H NMR (DMSO-d6) δ 9.15 (s, 1H), 6.91 (s, 1H), 6.24 (s, 1H), 4.90 (br s, 2H), 1.22 (s, 9H); ESI-MS 244.0 m/z (MH+).

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