반응 #161182

반응 방정식

2-tert-butyl-4-bromo-5-nitrophenol

Cs2CO3

benzyl bromide

→

1-tert-butyl-2-(benzyloxy)-5-bromo-4-nitrobenzene

수율 94.0%

용매

DMF

H2O

반응 조건

후처리

1. 1
   추출extracted twice with EtOAc
2. 2
   세척The combined organic layers were washed with brine
3. 3
   건조dried over MgSO4
4. 4
   기타After removal of solvent
5. 5
   기타the residue was purified by column chloromatography (0-5% EtOAc-Hexane)

실험 절차

To a mixture of 2-tert-butyl-4-bromo-5-nitrophenol (C-14-a) (1.1 g, 4 mmol) and Cs2CO3 (1.56 g, 4.8 mmol) in DMF (8 mL) was added benzyl bromide (500 μL, 4.2 mmol). The mixture was stirred at room temperature for 4 h, diluted with H2O and extracted twice with EtOAc. The combined organic layers were washed with brine and dried over MgSO4. After removal of solvent, the residue was purified by column chloromatography (0-5% EtOAc-Hexane) to yield 1-tert-butyl-2-(benzyloxy)-5-bromo-4-nitrobenzene (1.37 g, 94%). 1H NMR (400 MHz, CDCl3) 7.62 (s, 1H), 7.53 (s, 1H), 7.43 (m, 5H), 5.22 (s, 2H), 1.42 (s, 9H).

출처