반응 #161132

반응 방정식

4-tert-butyl-phenylamine

NBS

→

2-Bromo-4-tert-butyl-phenylamine

용매

DMF

DMF

water

반응 조건

후처리

1. 1
   추출extracted with EtOAc
2. 2
   세척The organic layer was washed with water, brine
3. 3
   건조dried over Na2SO4
4. 4
   농축concentrated
5. 5
   기타The crude product was directly used in the next step without further purification

실험 절차

To a solution of 4-tert-butyl-phenylamine (447 g, 3 mol) in DMF (500 mL) was added dropwise NBS (531 g, 3 mol) in DMF (500 mL) at room temperature. Upon completion, the reaction mixture was diluted with water and extracted with EtOAc. The organic layer was washed with water, brine, dried over Na2SO4 and concentrated. The crude product was directly used in the next step without further purification.

출처