반응 #161128

반응 방정식

1-benzenesulfonyl-5-ethyl-2,3-dihydro-1H-indole

NaOH

→

5-ethyl-2,3-dihydro-1H-indole

수율 34.0%

용매

HBr

반응 조건

후처리

1. 1
   온도was heated
2. 2
   온도at reflux for 6 h
3. 3
   추출extracted with ethyl acetate
4. 4
   세척The organic layer was washed with brine
5. 5
   건조dried over Na2SO4
6. 6
   농축concentrated under reduced pressure
7. 7
   기타The residue was purified by column chromatography on silica gel

실험 절차

A mixture of 1-benzenesulfonyl-5-ethyl-2,3-dihydro-1H-indole (15 g, 0.05 mol) in HBr (48%, 162 mL) was heated at reflux for 6 h. The mixture was basified with sat. NaOH solution to pH 9 and extracted with ethyl acetate. The organic layer was washed with brine, dried over Na2SO4 and concentrated under reduced pressure. The residue was purified by column chromatography on silica gel to give 5-ethyl-2,3-dihydro-1H-indole (2.5 g, 32%).

출처