반응 #160982

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5-bromo-6-chloro-N-(4-(2-chloro-1,1,2,2-tetrafluoroethyl)phenyl)nicotinamide

(R)-pyrrolidin-3-ol

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title compound

(R)-5-Bromo-N-(4-(2-chloro-1,1,2,2-tetrafluoroethyl)phenyl)-6-(3-hydroxypyrrolidin-1-yl)nicotinamide

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후처리

1. 1
   기타to afford a white powder

실험 절차

The title compound was prepared in an analogous fashion to that described in Stage 8.1 using 5-bromo-6-chloro-N-(4-(2-chloro-1,1,2,2-tetrafluoroethyl)phenyl)nicotinamide (Stage 31.2) and (R)-pyrrolidin-3-ol to afford a white powder. HPLC (Condition 4) tR=6.05 min, UPLC-MS (Condition 3) tR=1.18 min, m/z=498 [M+H]+.

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