반응 #160604

반응 방정식

3,4,6-trifluoro-N2-(2-Fluoro-4-iodo-phenyl)-benzene-1,2-diamine

(2-fluoro-4-iodo-phenyl)-(2,3,5-trifluoro-6-nitro-phenyl)-amine

1,1′-carbonyldiimidazole

→

4,6,7-Trifluoro-1-(2-Fluoro-4-iodo-phenyl)-1,3,-dihydrobenzoimidazole-2-one

수율 65.8%

용매

CH2Cl2

반응 조건

후처리

1. 1
   기타precipitated out
2. 2
   여과The white solid was filtered
3. 3
   기타used further without any purification

실험 절차

To the stirred solution of 3,4,6-trifluoro-N2-(2-Fluoro-4-iodo-phenyl)-benzene-1,2-diamine 3 (0.285 gm, 0.74 mmol) in CH2Cl2 (2 ml), 1,1′-carbonyldiimidazole (0.125 gm, 0.75 mmol) was added. This reaction mixture was kept stirring at room temperature for 16 hours when product precipitated out. The white solid was filtered and used further without any purification. (0.2 gm, yield: 65.85%): m/z=407 [M−1]−.

출처