반응 #1605828

반응 방정식

4-(Hydroxyethyl)phenol

potassium carbonate

1,2-dibromoethane

→

2-[4-(2-bromoethoxy)phenyl]-1-ethanol

수율 15.3%

용매

N,N-dimethylformamide

반응 조건

후처리

1. 1
   추출the reaction solution was extracted with ethyl acetate
2. 2
   세척The organic layer was washed with a saturated aqueous solution of sodium chloride
3. 3
   건조dried over anhydrous magnesium sulfate
4. 4
   농축concentrated under reduced pressure
5. 5
   기타The residue was purified by flash column chromatography

실험 절차

4-(Hydroxyethyl)phenol (2.7 g, 20.0 mmol) was dissolved in N,N-dimethylformamide (50 mL) and thereto were added potassium carbonate (6.90 g, 50.0 mmol) and 1,2-dibromoethane (15.03 g, 80.0 mmol). After stirring at 80° C. for 6 hours, the reaction solution was extracted with ethyl acetate. The organic layer was washed with a saturated aqueous solution of sodium chloride, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was purified by flash column chromatography to obtain 2-[4-(2-bromoethoxy)phenyl]-1-ethanol (750.0 mg).

출처