반응 #1605825

반응 방정식

4-Bromo-3-nitrobenzoic acid

phenyl boric acid

cesium carbonate

→

3-nitro-4-phenylbenzoic acid

용매

1,4-dioxane

반응 조건

후처리

1. 1
   기타purified water (10 mL)
2. 2
   여과The reaction solution was filtered through celite, alumina, and Florisil
3. 3
   추출was extracted with ethyl acetate
4. 4
   세척The organic layer was washed with a saturated aqueous solution of sodium chloride
5. 5
   건조dried over anhydrous magnesium sulfate
6. 6
   농축concentrated under reduced pressure

실험 절차

4-Bromo-3-nitrobenzoic acid (1.0 g, 2.5 mmol) was dissolved in 1,4-dioxane (30 mL), and, thereto were added phenyl boric acid (610 mg, 5.0 mmol), cesium carbonate (6.5 g, 20.0 mmol), 1,1-[bis(diphenylphosphino)ferrocene]dichloropalladium(II) dichloromethane complex (204 mg, 0.10 mmol), and purified water (10 mL). The reaction mixture was stirred under a nitrogen flow at 80° C. overnight. The reaction solution was filtered through celite, alumina, and Florisil, and, thereafter, was extracted with ethyl acetate. The organic layer was washed with a saturated aqueous solution of sodium chloride, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to obtain 3-nitro-4-phenylbenzoic acid as a crude material.

출처