반응 #1605821

반응 방정식

5-Acetyl-8-hydroxy-1H-quinolin-2-one

potassium carbonate

4-methoxybenzyl chloride

→

5-acetyl-8-[(4-methoxyphenyl)methoxy]-1,2-dihydroquinolin-2-one

수율 53.8%

용매

N,N-dimethylformamide

반응 조건

후처리

1. 1
   workup.ADDITIONTo the reaction mixture was added
2. 2
   기타purified water (0.5 L)
3. 3
   workup.STIRRINGthe mixture was stirred at room temperature overnight
4. 4
   여과The precipitate was collected by filtration
5. 5
   세척washed with purified water
6. 6
   기타dried under reduced pressure

실험 절차

5-Acetyl-8-hydroxy-1H-quinolin-2-one (29.5 g, 0.15 mol) was suspended in N,N-dimethylformamide (145 mL), potassium carbonate (22.2 g, 0.16 mol) and successively 4-methoxybenzyl chloride (22.7 g, 0.15 mol) were added thereto, and the mixture was stirred at 90° C. overnight. To the reaction mixture was added purified water (0.5 L) and the mixture was stirred at room temperature overnight. The precipitate was collected by filtration, washed with purified water, dried under reduced pressure to obtain 5-acetyl-8-[(4-methoxyphenyl)methoxy]-1,2-dihydroquinolin-2-one (26.1 g).

출처