반응 #1605820

반응 방정식

3-Nitro-4-phenylphenol

tert-butyl 2-bromoacetate

→

tert-butyl 2-(3-nitro-4-phenylphenoxy)acetate

수율 112.3%

용매

N,N-dimethylformamide

반응 조건

후처리

1. 1
   추출the reaction solution was extracted with ethyl acetate
2. 2
   세척The organic layer was washed with a saturated aqueous solution of sodium chloride
3. 3
   건조dried over anhydrous magnesium sulfate
4. 4
   농축concentrated under reduced pressure
5. 5
   기타The residue was purified by flash column chromatography

실험 절차

3-Nitro-4-phenylphenol (215 mg, 1.0 mmol) was dissolved in N,N-dimethylformamide (5 mL) and tert-butyl 2-bromoacetate (292 mg, 1.5 mmol) was added thereto. After stirring at 80° C. for 18 hours, the reaction solution was extracted with ethyl acetate. The organic layer was washed with a saturated aqueous solution of sodium chloride, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was purified by flash column chromatography to obtain tert-butyl 2-(3-nitro-4-phenylphenoxy)acetate (370 mg).

출처