반응 #1605819

반응 방정식

4-(Hydroxymethyl)phenol

potassium carbonate

4-bromo-1-butene

→

[4-(2-propenoyloxy)phenyl]methanol

수율 30.0%

용매

N,N-dimethylformamide

반응 조건

후처리

1. 1
   추출the reaction solution was extracted with ethyl acetate
2. 2
   세척The organic layer was washed with a saturated aqueous solution of sodium chloride
3. 3
   건조dried over anhydrous magnesium sulfate
4. 4
   농축concentrated under reduced pressure
5. 5
   기타The residue was purified by flash column chromatography

실험 절차

4-(Hydroxymethyl)phenol (620 mg, 5.0 mmol) was dissolved in N,N-dimethylformamide (25 ml) and potassium carbonate (1.38 g, 10.0 mmol) and 4-bromo-1-butene (1.08 g, 8.0 mmol) were added thereto. After stirring at 70° C. for 4 hours, the reaction solution was extracted with ethyl acetate. The organic layer was washed with a saturated aqueous solution of sodium chloride, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was purified by flash column chromatography to obtain [4-(2-propenoyloxy)phenyl]methanol (267 mg).

출처