반응 #1605817

반응 방정식

3-Nitro-4-phenylphenol

8-bromo-1-octanol

→

8-(3-nitro-4-phenylphenoxy)octan-1-ol

수율 89.5%

용매

N,N-dimethylformamide

반응 조건

후처리

1. 1
   추출the reaction solution was extracted with ethyl acetate
2. 2
   세척The organic layer was washed with a saturated aqueous solution of sodium chloride
3. 3
   건조dried over anhydrous magnesium sulfate
4. 4
   농축concentrated under reduced pressure
5. 5
   기타The residue was purified by flash column chromatography

실험 절차

3-Nitro-4-phenylphenol (860 mg, 4.0 mmol) was dissolved in N,N-dimethylformamide (40 mL), followed by addition of 8-bromo-1-octanol (1.86 g, 6.0 mmol). After stirring at 50° C. for 5 hours, the reaction solution was extracted with ethyl acetate. The organic layer was washed with a saturated aqueous solution of sodium chloride, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was purified by flash column chromatography to obtain 8-(3-nitro-4-phenylphenoxy)octan-1-ol (1.23 g).

출처