반응 #1605816

반응 방정식

boron tribromide

4-Methoxy-2-nitro-1-phenylbenzene

→

3-nitro-4-phenylphenol

용매

dichloromethane

dichloromethane

반응 조건

후처리

1. 1
   workup.ADDITIONwas added, under ice-water cooling
2. 2
   workup.ADDITIONthe reaction mixture was poured onto ice
3. 3
   기타the reaction
4. 4
   추출extracted with ethyl acetate
5. 5
   세척The organic layer was washed with a saturated aqueous solution of sodium chloride
6. 6
   건조dried over anhydrous magnesium sulfate
7. 7
   농축concentrated under reduced pressure

실험 절차

4-Methoxy-2-nitro-1-phenylbenzene (1.86 g, 8.31 mmol) was dissolved in dichloromethane (40 mL) and thereto was added, under ice-water cooling, a solution of boron tribromide (2 mL) in dichloromethane (10 mL) After stirring at room temperature for 18 hours, the reaction mixture was poured onto ice to stop the reaction and extracted with ethyl acetate. The organic layer was washed with a saturated aqueous solution of sodium chloride, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to obtain 3-nitro-4-phenylphenol as a crude material.

출처