반응 #1605812

반응 방정식

2-Phenyl-N-acetylaniline

hydrogen bromide

→

2-phenyl-4-bromo-N-acetylaniline

수율 91.3%

용매

carbon tetrachloride

acetic acid

반응 조건

후처리

1. 1
   농축The solution was concentrated under reduced pressure, to the residue
2. 2
   workup.ADDITIONwas added water (20 mL) and subsequently ethanol (30 mL)
3. 3
   workup.STIRRINGthe mixture was stirred under ice bath for 1 hour
4. 4
   여과The precipitate was collected by filtration
5. 5
   세척washed with ethanol/water (=1:1)
6. 6
   기타dried under reduced pressure

실험 절차

2-Phenyl-N-acetylaniline (6.21 g, 29.40 mmol) was dissolved in acetic acid (70 mL). Thereto was dropwise added under ice bath a separately prepared solution of hydrogen bromide (6.14 g, 38.42 mmol) dissolved in carbon tetrachloride (19.21 mL) and the mixture was stirred at room temperature overnight. The solution was concentrated under reduced pressure, to the residue was added water (20 mL) and subsequently ethanol (30 mL), and the mixture was stirred under ice bath for 1 hour. The precipitate was collected by filtration, washed with ethanol/water (=1:1), dried under reduced pressure to obtain 2-phenyl-4-bromo-N-acetylaniline (7.79 g).

출처