반응 #1605810

반응 방정식

2-Methyl-4-nitrobenzoic acid

→

4-amino-2-methylbenzoic acid

용매

methanol

반응 조건

후처리

1. 1
   여과The reaction solution was filtered through celite
2. 2
   농축the filtrate was concentrated under reduced pressure

실험 절차

2-Methyl-4-nitrobenzoic acid (741 g, 5 mmol) was dissolved in methanol (20 mL), 10% palladium-carbon (100 mg) was added, and the mixture was stirred under a hydrogen atmosphere at room temperature for 16 hours. The reaction solution was filtered through celite and, thereafter, the filtrate was concentrated under reduced pressure to obtain 4-amino-2-methylbenzoic acid as a crude material. In accordance with Reference Example 23 and Reference Example 14, from 4-amino-2-methylbenzoic acid obtained, there was obtained 4-[(tert-butyldimethylsilanoyloxy)methyl]-3-methylaniline (0.33 g).

출처