반응 #1605781

반응 방정식

para-tolylisocyanate

toluene

2-isopropylcyclohexanol

→

product

수율 56.8%

p-Tolyl-carbamic acid 2-isopropyl-cyclohexyl ester

수율 56.8%

용매

water

반응 조건

후처리

1. 1
   온도The reaction mixture was heated
2. 2
   온도to reflux for 6 hours
3. 3
   workup.ADDITIONwere added
4. 4
   온도the mixture was refluxed for one more hour
5. 5
   기타After phase separation the solvent
6. 6
   기타the crude product recrystallized from 235 g of n-heptane

실험 절차

75.6 g (0.56 mol) of para-tolylisocyanate were placed with 500 ml toluene in a one litre vessel and subsequently 73.4 g (0.51 mol) of 2-isopropylcyclohexanol were added. The reaction mixture was heated to reflux for 6 hours. After cooling to room temperature 50 g of water were added and the mixture was refluxed for one more hour. After phase separation the solvent was stripped off and the crude product recrystallized from 235 g of n-heptane. The product (79.8 g) was obtained in form of off-white crystals in 99.2% purity. This corresponds to a theoretical yield of 56%.

출처