반응 #1605751

반응 방정식

2-methylheptan-4-one

ammonium acetate

sodium cyanoborohydride

→

2-methylheptan-4-amine

수율 77.2%

용매

methanol

반응 조건

후처리

1. 1
   기타The solvent was removed under reduced pressure
2. 2
   workup.ADDITIONthe residue was diluted with water and basified with 15% NaOH aqueous
3. 3
   추출extracted with ether
4. 4
   세척The extract was washed with brine
5. 5
   건조dried over anhydrous magnesium sulfate
6. 6
   여과filtered
7. 7
   기타evaporated

실험 절차

To a solution of 2-methylheptan-4-one (4.24 g, 33.07 mmol), in methanol (60 mL), were added ammonium acetate (25.50 g, 330.71 mmol) and sodium cyanoborohydride (2.08 g, 33.07 mmol). The reaction mixture was stirred at room temperature for about 24 hours. The solvent was removed under reduced pressure and the residue was diluted with water and basified with 15% NaOH aqueous and extracted with ether. The extract was washed with brine, dried over anhydrous magnesium sulfate, filtered and evaporated to give 3.3 g of 2-methylheptan-4-amine (77%). MS (M+H, 130).

출처