반응 #160526

반응 방정식

hydrochloric acid

1,4-difluoro-2-methyl-5-nitrobenzene

cyanoacetic acid benzyl ester

potassium carbonate

→

title compound

수율 81.4%

Cyano-(4-fluoro-5-methyl-2-nitrophenyl)acetic acid benzyl ester

수율 81.4%

용매

N,N-dimethylformamide

반응 조건

후처리

1. 1
   추출this mixture was extracted with diethyl ether
2. 2
   세척This organic layer was washed with brine
3. 3
   건조dried over anhydrous magnesium sulfate
4. 4
   여과filtered
5. 5
   기타The solvent was removed under reduced pressure
6. 6
   세척This residue was washed with ethanol

실험 절차

A suspension of 1,4-difluoro-2-methyl-5-nitrobenzene (1.00 g), cyanoacetic acid benzyl ester (1.01 g) and potassium carbonate (1.76 g) in N,N-dimethylformamide (20.0 mL) was stirred at 60° C. for 1 day. To this reaction mixture was added 1 mol/L hydrochloric acid (25.4 mL), and this mixture was extracted with diethyl ether. This organic layer was washed with brine, and dried over anhydrous magnesium sulfate, and filtered. The solvent was removed under reduced pressure. This residue was washed with ethanol to give the title compound (1.54 g).

출처