반응 #160512

반응 방정식

(Z)-3-(5-benzyloxy-2-bromo-4-methylphenyl)-2-benzyloxycarbonylaminoacrylic acid methyl ester

cesium acetate

ammonia

→

title compound

수율 63.1%

5-Benzyloxy-6-methyl-1H-indole-2-carboxylic acid methyl ester

수율 63.1%

용매

dimethylsulfoxide

반응 조건

후처리

1. 1
   여과the precipitated solid was collected by filtration
2. 2
   세척washed with water
3. 3
   기타dried under reduced pressure

실험 절차

To a solution of (Z)-3-(5-benzyloxy-2-bromo-4-methylphenyl)-2-benzyloxycarbonylaminoacrylic acid methyl ester (0.2 g) and copper (I) iodide (0.075 g) in dimethylsulfoxide (8 mL) was added cesium acetate (0.38 g) at room temperature and this mixture was stirred under argon atmosphere at 90° C. for 5 hours. To this reaction mixture was added aqueous ammonia solution (28%) and the precipitated solid was collected by filtration, and washed with water, dried under reduced pressure to give the title compound (0.073 g).

출처