반응 #1605070

ord-d312f5db9a7d43e6b760dd9afd9ab837

반응 방정식

COc1cc2nccc(Oc3ccc(NC(=O)c4c(C)n(C[C@@H](C)OC(=O)[C@H](C)N)n(-c5ccccc5)c4=O)cc3F)c2cc1OC
(S)—((R)-1-(4-(4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenyl-carbamoyl)-5-methyl-3-oxo-2-phenyl-2,3-dihydropyrazol-1-yl)propan-2-yl)2-aminopropanoate
Cl
HCl
→
COc1cc2nccc(Oc3ccc(NC(=O)c4c(C)n(C[C@@H](C)OC(=O)[C@H](C)N)n(-c5ccccc5)c4=O)cc3F)c2cc1OC.Cl
title compound
COc1cc2nccc(Oc3ccc(NC(=O)c4c(C)n(C[C@@H](C)OC(=O)[C@H](C)N)n(-c5ccccc5)c4=O)cc3F)c2cc1OC.Cl
(S)—((R)-1-(4-(4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenylcarbamoyl)-5-methyl-3-oxo-2-phenyl-2,3-dihydropyrazol-1-yl)propan-2-yl)2-aminopropanoate hydrochloride

반응물

COc1cc2nccc(Oc3ccc(NC(=O)c4c(C)n(C[C@@H](C)OC(=O)[C@H](C)N)n(-c5ccccc5)c4=O)cc3F)c2cc1OC
(S)—((R)-1-(4-(4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenyl-carbamoyl)-5-methyl-3-oxo-2-phenyl-2,3-dihydropyrazol-1-yl)propan-2-yl)2-aminopropanoate
Cl
HCl

시약

없음

용매

CCOC(C)=O
EtOAc

반응 조건

상세 조건
See reaction.notes.procedure_details.

후처리

  1. 1
    기타The title compound was prepared

실험 절차

The title compound was prepared according to the procedure described in Example 1 Step 3 by using (S)—((R)-1-(4-(4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenyl-carbamoyl)-5-methyl-3-oxo-2-phenyl-2,3-dihydropyrazol-1-yl)propan-2-yl)2-aminopropanoate (165.3 mg, 0.257 mmol) and a saturated HCl solution in EtOAc (5 mL). The title compound was obtained as a pale yellow solid (160 mg, 87%).

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US08232294B2uspto-grants-2012_07