반응 #1605067

반응 방정식

(R)-1-(4-(4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenylcarbamoyl)-5-methyl-3-oxo-2-phenyl-2,3-dihydropyrazol-1-yl)propan-2-yl-2-(tert-butoxycarbonyl amino)acetate

HCl

→

title compound

수율 83.0%

(R)-1-(4-(4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenylcarbamoyl)-5-methyl-3-oxo-2-phenyl-2,3-dihydropyrazol-1-yl)propan-2-yl 2-aminoacetate hydro-chloride

수율 83.0%

용매

EtOAc

EtOAc

반응 조건

후처리

1. 1
   기타The solid formed
2. 2
   기타was collected
3. 3
   기타was crystallized in MeOH/EtOAc (20 mL, v/v=1:5)
4. 4
   세척The product was further washed with EtOAc (5 mL×3)
5. 5
   기타dried under vacuum overnight

실험 절차

To a solution of (R)-1-(4-(4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenylcarbamoyl)-5-methyl-3-oxo-2-phenyl-2,3-dihydropyrazol-1-yl)propan-2-yl-2-(tert-butoxycarbonyl amino)acetate (100 mg, 0.137 mmol) in EtOAc (15 mL) was added 3 mL of saturated HCl in EtOAc (3 mL). The reaction mixture was stirred at rt overnight. The solid formed was collected and was crystallized in MeOH/EtOAc (20 mL, v/v=1:5). The product was further washed with EtOAc (5 mL×3) and dried under vacuum overnight to afford the title compound as a white solid (88 mg, 83%).

출처