반응 #160504

반응 방정식

water

6-fluoro-1H-indole-3-carbaldehyde

hydroxylamine

sodium formate

→

title compound

수율 59.9%

6-Fluoro-1H-indole-3-carbonitrile

수율 59.9%

용매

formic acid

반응 조건

후처리

1. 1
   온도After cooling to ambient temperature
2. 2
   여과the precipitated solid was collected by filtration
3. 3
   세척washed with water
4. 4
   기타dried

실험 절차

To a solution of 6-fluoro-1H-indole-3-carbaldehyde (0.97 g) in 90% formic acid (25 mL) were added hydroxylamine (0.65 g) and sodium formate (0.81 g), and this mixture was stirred at 100° C. for 3 hours. After cooling to ambient temperature, water was added to this reaction mixture and the precipitated solid was collected by filtration, and washed with water, dried to give the title compound (0.57 g).

출처