반응 #160412

반응 방정식

2-cyclohexanesulfonyl-2-methyl-propionic acid ethyl ester

lithium hydroxide monohydrate

→

2-cyclohexanesulfonyl-2-methyl-propionic acid

수율 95.7%

용매

water

THF water

반응 조건

후처리

1. 1
   세척washed with DCM (2×15 mL)
2. 2
   온도The basic aqueous layer was cooled in an ice bath
3. 3
   추출The acidic aqueous layer was extracted with DCM (3×20 mL)
4. 4
   세척The combined organic extracts were washed with brine
5. 5
   건조dried over Na2SO4
6. 6
   여과filtered

실험 절차

To a solution of 3.47 g (13.2 mmol) of 2-cyclohexanesulfonyl-2-methyl-propionic acid ethyl ester in THF/water (4/1, 50 mL) were added 1.11 g (26.4 mmol) of lithium hydroxide monohydrate. The reaction was stirred at room temperature for 18 h. The reaction was further diluted with water (20 mL) and then washed with DCM (2×15 mL). The basic aqueous layer was cooled in an ice bath and then acidified with 1M aqueous HCl solution to pH 2. The acidic aqueous layer was extracted with DCM (3×20 mL). The combined organic extracts were washed with brine, dried over Na2SO4 and filtered. Concentration of the filtrate under reduced pressure afforded 2.96 g of 2-cyclohexanesulfonyl-2-methyl-propionic acid.

출처