반응 #160380

반응 방정식

acetic anhydride

(1R,2S,4R)-2-Hydroxy-4-methyl-cyclohexanecarboxylic acid

pyridine

→

(1R,2S,4R)-2-Acetoxy-4-methyl-cyclohexanecarboxylic acid

수율 53.4%

용매

dichloromethane

반응 조건

후처리

1. 1
   기타Then, the solvents were removed
2. 2
   workup.ADDITION10 ml of 3N HCl solution was added
3. 3
   workup.STIRRINGThis mixture was stirred for 30 minutes
4. 4
   workup.ADDITIONa saturated solution of NaHCO3 was slowly added until PH=9-10
5. 5
   추출This solution was then extracted with ethyl acetate (2×5 ml)
6. 6
   추출extracted with ethyl acetate (3×5 ml)
7. 7
   건조dried (Na2SO4)
8. 8
   농축concentrated

실험 절차

To a solution of (1R,2S,4R)-2-Hydroxy-4-methyl-cyclohexanecarboxylic acid (162 mg, 1.02 mmol) in dichloromethane (5 ml) was added pyridine (495 ul, 6.12 mmol) followed by acetic anhydride (385 ul, 4.08 mmol). The reaction mixture was stirred for 20 h at room temperature. Then, the solvents were removed and 10 ml of 3N HCl solution was added. This mixture was stirred for 30 minutes and then a saturated solution of NaHCO3 was slowly added until PH=9-10. This solution was then extracted with ethyl acetate (2×5 ml). The aqueous phase was then acidified with a 10% HCl solution and extracted with ethyl acetate (3×5 ml). The following ethyl acetate layers were combined, dried (Na2SO4) and concentrated to obtain 109 mg (53%) of (1R,2S,4R)-2-Acetoxy-4-methyl-cyclohexanecarboxylic acid.

출처