반응 #160253

ord-135a35cdfaff4cfda5129b53a6dceca7

반응 방정식

Fc1ncc(Cl)cc1Cl
3,5-dichloro-2-fluoropyridine
CCOC(=O)c1ccc(S(=O)(=O)NCc2ccc3c(ccn3C)c2)c(Cl)c1
ethyl 3-chloro-4-(N-((1-methyl-1H-indol-5-yl)methyl)sulfamoyl)benzoate
CCOC(=O)c1ccc(S(=O)(=O)NCc2ccc3c(ccn3C)c2)c(Cl)c1
Ethyl 3-chloro-4-(N-((1-methyl-1H-indol-5-yl)methyl)sulfamoyl)benzoate
→
CCOC(=O)c1ccc(S(=O)(=O)N(Cc2ccc3c(ccn3C)c2)c2ncc(Cl)cc2Cl)c(Cl)c1
titled compound
CCOC(=O)c1ccc(S(=O)(=O)N(Cc2ccc3c(ccn3C)c2)c2ncc(Cl)cc2Cl)c(Cl)c1
Ethyl 3-chloro-4-(N-(3,5-dichloropyridin-2-yl)-N-((1-methyl-1H-indol-5-yl)methyl)sulfamoyl)benzoate

반응물

Fc1ncc(Cl)cc1Cl
3,5-dichloro-2-fluoropyridine
CCOC(=O)c1ccc(S(=O)(=O)NCc2ccc3c(ccn3C)c2)c(Cl)c1
ethyl 3-chloro-4-(N-((1-methyl-1H-indol-5-yl)methyl)sulfamoyl)benzoate
CCOC(=O)c1ccc(S(=O)(=O)NCc2ccc3c(ccn3C)c2)c(Cl)c1
Ethyl 3-chloro-4-(N-((1-methyl-1H-indol-5-yl)methyl)sulfamoyl)benzoate

시약

없음

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

The titled compound was prepared according to the procedure described in step-2 of Example 1 from 3,5-dichloro-2-fluoropyridine and ethyl 3-chloro-4-(N-((1-methyl-1H-indol-5-yl)methyl)sulfamoyl)benzoate (step-1 of Example 8).

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US08829026B2uspto-grants-2014_09