반응 #160233

반응 방정식

Tert-butyl 8-benzyl-9,9-dimethyl-11-oxa-3,8-diazaspiro[5.5]undecane-3-carboxylate

hydrogen chloride

dioxane

→

8-benzyl-9,9-dimethyl-11-oxa-3,8-diazaspiro[5.5]undecane hydrochloride

수율 86.0%

반응 조건

후처리

1. 1
   농축The reaction mixture was concentrated in vacuo

실험 절차

Tert-butyl 8-benzyl-9,9-dimethyl-11-oxa-3,8-diazaspiro[5.5]undecane-3-carboxylate (89 mg, 0.24 mmol) was treated with hydrogen chloride solution in dioxane (240 μL of 4 M, 0.95 mmol). The reaction mixture was stirred for 18 h. The reaction mixture was concentrated in vacuo to provide 8-benzyl-9,9-dimethyl-11-oxa-3,8-diazaspiro[5.5]undecane hydrochloride (56 mg, 86%). ESI-MS m/z calc. 274.4. Found 275.5 (M+1)+; Retention time: 0.80 minutes (3 min run).

출처