반응 #159950

반응 방정식

sulfuric acid

1-(4-fluoro-2-methoxyphenyl)ethanone

potassium nitrate

→

title compound

수율 92.8%

1-(4-Fluoro-2-methoxy-5-nitrophenyl)ethanone

수율 92.8%

용매

반응 조건

후처리

1. 1
   온도by heating to homogeneity
2. 2
   workup.ADDITIONwas added little by little,
3. 3
   workup.WAITfollowed by an hour
4. 4
   기타The reaction liquid
5. 5
   여과the precipitated crystals were recovered by filtration
6. 6
   세척washed with water
7. 7
   기타Drying the crystals

실험 절차

In nitrogen atmosphere, cone. sulfuric acid 36 mL was added to 1-(4-fluoro-2-methoxyphenyl)ethanone 5.50 g, followed by heating to homogeneity. Cooling the same with salt-ice, potassium nitrate 3.47 g was added little by little, followed by an hour's stirring. The reaction liquid was poured in ice water, and the precipitated crystals were recovered by filtration and washed with water. Drying the crystals, 6.47 g of the title compound was obtained.

출처