반응 #1596952

반응 방정식

1,2-dibromoethane

n-butyl lithium hexane

THF

dibenzofuran

→

Compound 16-1

Bromodibenzofuran

용매

Water

반응 조건

후처리

1. 1
   온도The obtained solution is again cooled to −78° C.
2. 2
   온도the temperature of the solution is raised to room temperature over 120 minutes
3. 3
   기타the reaction
4. 4
   추출Organic layers extracted from the obtained mixture with ethyl acetate
5. 5
   건조are dried with sodium sulfate
6. 6
   농축concentrated with an evaporator

실험 절차

Under nitrogen current at −78° C., an n-butyl lithium hexane solution (1.6M, 69 ml) is dropped to a THF solution (175 ml) containing 16.82 g of dibenzofuran, and the temperature of the mixture is raised to room temperature over 80 minutes. The obtained solution is again cooled to −78° C., 19.0 ml of 1,2-dibromoethane is added to the solution, and the temperature of the solution is raised to room temperature over 120 minutes. Water is added to the obtained reaction solution to stop the reaction. Organic layers extracted from the obtained mixture with ethyl acetate are dried with sodium sulfate, and then concentrated with an evaporator to obtain 12.35 g of Compound 16-1.

출처