반응 #1596945

반응 방정식

2-(4-benzyloxy-3-fluorophenyl)-4-bromo-5-propyltetrahydropyran

triethylamine

→

2-fluoro-4-(5-propyltetrahydropyran-2-yl)phenol

용매

MTBE

toluene water

반응 조건

후처리

1. 1
   기타the organic phase is separated off
2. 2
   추출The aqueous phase is extracted with MTBE
3. 3
   세척The combined organic phases are washed with water
4. 4
   기타dried
5. 5
   농축The solution is concentrated to dryness
6. 6
   기타the residue is used directly for the following reaction

실험 절차

123.0 g (0.30 mol) of 2-(4-benzyloxy-3-fluorophenyl)-4-bromo-5-propyltetrahydropyran are hydrogenated in toluene/water in the presence of Pd/C (5% of Pd) and 86.0 ml (0.60 mol) of triethylamine. The reaction solution is diluted with MTBE, and the organic phase is separated off. The aqueous phase is extracted with MTBE. The combined organic phases are washed with water and dried using sodium sulfate. The solution is concentrated to dryness, and the residue is used directly for the following reaction.

출처