반응 #1596942

반응 방정식

4-bromo-2-fluorophenol

potassium carbonate

benzyl bromide

→

1-benzyloxy-4-bromo-2-fluorobenzene

용매

ethyl methyl ketone

반응 조건

후처리

1. 1
   온도The mixture is refluxed for 5 h
2. 2
   여과The batch is filtered
3. 3
   농축the filtrate is concentrated to dryness
4. 4
   기타The crude product is crystallised from heptane at reduced temperature

실험 절차

210.0 g (1.10 mol) of 4-bromo-2-fluorophenol are dissolved in 1.1 l of ethyl methyl ketone, and 175.0 g (1.27 mol) of potassium carbonate and 150.0 ml (1.26 mol) of benzyl bromide are added. The mixture is refluxed for 5 h and stirred at room temperature for 16 h. The batch is filtered, and the filtrate is concentrated to dryness. The crude product is crystallised from heptane at reduced temperature.

출처