반응 #159640

반응 방정식

methyl 2-(2-benzylpyrrolidin-1-yl)-5-chloronicotinate

lithium hydroxide monohydrate

→

title compound ( D100 )

수율 97.8%

2-(2-benzylpyrrolidin-1-yl)-5-chloronicotinic acid

수율 97.8%

용매

1,4-dioxane water

반응 조건

후처리

1. 1
   기타Solvents were evaporated in vacuo
2. 2
   workup.ADDITIONThe obtained residue was diluted with water/1M HCl (5 ml/15 ml)
3. 3
   추출extracted with ethyl acetate (3×30 ml)
4. 4
   기타Collected fractions after solvent evaporation

실험 절차

To methyl 2-(2-benzylpyrrolidin-1-yl)-5-chloronicotinate (D74) (75 mg, 0.226 mmol) in a mixture 1,4-dioxane/water (3 ml/1 ml), lithium hydroxide monohydrate (14.3 mg, 0.34 mmol) was added and the resulting mixture was stirred at 150° C. under microwave irradiation for 10 min (2 cycles of 5 min each). Solvents were evaporated in vacuo. The obtained residue was diluted with water/1M HCl (5 ml/15 ml) and extracted with ethyl acetate (3×30 ml). Collected fractions after solvent evaporation afforded the title compound (D100) (70 mg).

출처