반응 #159487

반응 방정식

Pivaloyl chloride

3-(3,5-dimethylbiphen-4-yl)bicyclo[3.2.1]octane-2,4-dione

triethylamine

→

3-(3,5-dimethylbiphen-4-yl)-4-oxo-bicyclo[3.2.1]oct-2-en-2-yl 2,2-dimethylpropionate

용매

dichloromethane

반응 조건

후처리

1. 1
   기타The reaction mixture is evaporated under reduced pressure
2. 2
   기타the residue is purified by column chromatography on silica gel

실험 절차

Pivaloyl chloride (248 μl, 2 mmol) is added to a solution of 3-(3,5-dimethylbiphen-4-yl)bicyclo[3.2.1]octane-2,4-dione (148 mg, 0.46 mmol) in dichloromethane (10 ml) and triethylamine (280 μl, 2 mmol) at room temperature. The reaction mixture is stirred at room temperature overnight. The reaction mixture is evaporated under reduced pressure and the residue is purified by column chromatography on silica gel to afford 3-(3,5-dimethylbiphen-4-yl)-4-oxo-bicyclo[3.2.1]oct-2-en-2-yl 2,2-dimethylpropionate.

출처