반응 #159376

반응 방정식

4-fluoro-2-methyl-1-nitrobenzene

dimethylpyrrolidin-3-ylamine

potassium carbonate

→

Dimethyl-[1-(3-methyl-4-nitrophenyl)pyrrolidin-3-yl]amine

용매

DMF

반응 조건

후처리

1. 1
   기타The reaction mixture was partitioned between water and ethyl acetate
2. 2
   기타The organic phase was dried
3. 3
   농축concentrated
4. 4
   기타The product with the molecular weight of 249.32 (C13H19N3O2) was obtained in this way

실험 절차

A mixture of 4-fluoro-2-methyl-1-nitrobenzene (13.6 g), dimethylpyrrolidin-3-ylamine (10.0 g), potassium carbonate (12 g) and DMF (100 mL) was stirred at room temperature for 4 hours. The reaction mixture was partitioned between water and ethyl acetate. The organic phase was dried and concentrated. The product with the molecular weight of 249.32 (C13H19N3O2) was obtained in this way; MS (ESI): 250 (M+H+).

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