반응 #159278

반응 방정식

TSTU

mono-tert-butyl octadecanedioate

DIPEA

→

succinimidyl tert-butyl octadecandioate

수율 29.0%

용매

THF

반응 조건

후처리

1. 1
   기타The solvent had evaporated
2. 2
   workup.ADDITIONAcOEt was added to the residue
3. 3
   여과the resulting suspension was filtered
4. 4
   세척The filtrate was washed with cold 0.1 M HCl (2×) and water
5. 5
   기타dried
6. 6
   농축concentrated

실험 절차

To a solution of mono-tert-butyl octadecanedioate (1,00 g, 2.7 mmol) in dry THF (8 ml), was added DIPEA (0,555 ml, 3.2 mmol) followed by TSTU (1,00 g, 3.2 mmol). The reaction mixture was stirred under nitrogen for 18 h. The solvent had evaporated. AcOEt was added to the residue and the resulting suspension was filtered. The filtrate was washed with cold 0.1 M HCl (2×) and water, dried and concentrated to give succinimidyl tert-butyl octadecandioate as a white solid.

출처