반응 #159276

반응 방정식

Mono-methyl hexadecandioate

succinimidyl tetramethyluroniumtetrafluoroborate

N,N-diisopropylethylamine

→

methyl succinimidyl hexadecandioate

수율 96.8%

용매

THF

반응 조건

후처리

1. 1
   기타The solvent was removed in vacuo
2. 2
   workup.DISSOLUTIONthe residue was dissolved in ethyl acetate
3. 3
   세척washed with 0.1 M HCl (twice) and water
4. 4
   건조The organic phase was dried over MgSO4
5. 5
   여과filtered
6. 6
   기타evaporated in vacuo

실험 절차

Mono-methyl hexadecandioate (275 mg, 0.91 mmol) was dissolved in THF (3 ml) and treated with succinimidyl tetramethyluroniumtetrafluoroborate (331 mg, 1.1 mmol) and N,N-diisopropylethylamine (188 μL, 1.1 mmol), and the mixture was stirred for 20 hours. The solvent was removed in vacuo, and the residue was dissolved in ethyl acetate and washed with 0.1 M HCl (twice) and water. The organic phase was dried over MgSO4, filtered and evaporated in vacuo to give 350 mg (96%) of methyl succinimidyl hexadecandioate.

출처