반응 #159015

반응 방정식

2-[5-(6-Bromonaphthalen-2-yl)-1H-imidazol-2-yl]-pyrrolidine-1-carboxylic acid tert-butyl ester

trifluoroacetic acid

→

5-(6-Bromo-naphthalen-2-yl)-2-pyrrolidin-2-yl-1H-imidazole

수율 98.0%

용매

dichloromethane

반응 조건

후처리

1. 1
   기타evaporated under vacuum
2. 2
   workup.DISSOLUTIONSolid was dissolved in dichloromethane (50 mL)
3. 3
   추출extracted with saturated NaHCO3 solution (50 mL)
4. 4
   여과Solid was collected by vacuum filtration
5. 5
   세척washed with dichloromethane
6. 6
   기타dried under vacuum

실험 절차

2-[5-(6-Bromonaphthalen-2-yl)-1H-imidazol-2-yl]-pyrrolidine-1-carboxylic acid tert-butyl ester (5.03 g) was dissolved in dichloromethane (75 mL), and trifluoroacetic acid (25 mL) was added. The reaction mixture was stirred at ambient temperature for 5 hours and evaporated under vacuum. Solid was dissolved in dichloromethane (50 mL) and extracted with saturated NaHCO3 solution (50 mL). Solid was collected by vacuum filtration, washed with dichloromethane, and dried under vacuum, giving 5-(6-Bromo-naphthalen-2-yl)-2-pyrrolidin-2-yl-1H-imidazole (98%) as an off-white solid.

출처