반응 #158904

반응 방정식

2-oxo-1,2-dihydro-pyridine-4-carboxylic acid methyl ester

tetrabutylammonium hydroxide

toluene

ammonium hydroxide

→

1-(4-Ethoxycarbonyl-phenyl)-2-oxo-1,2-dihydro-pyridine-4-carboxylic acid

용매

H2O

반응 조건

후처리

1. 1
   농축Mixture was concentrated
2. 2
   기타dried under high vacuum
3. 3
   workup.ADDITIONTo the residue was added 4-Iodo-benzoic acid ethyl ester (2.40 g)
4. 4
   workup.ADDITIONCopper iodide (0.829 g) and DMF (10 mL) were added
5. 5
   기타reaction mixture
6. 6
   온도heated at 95° C. for 18 hours
7. 7
   기타To the cooled reaction mixture
8. 8
   추출extracted with dichloromethane (4×)
9. 9
   건조Organic layer was dried (MgSO4)
10. 10
    농축concentrated
11. 11
    기타purified by flash column chromatography (silica gel, 0 to 5% methanol/dichloromethane+1% triethylamine)

실험 절차

A mixture of 2-oxo-1,2-dihydro-pyridine-4-carboxylic acid methyl ester (2.00 g), 1.0M tetrabutylammonium hydroxide in H2O (13 ml) and toluene (50 mL) was stirred for 2 hours at ambient temperature. Mixture was concentrated and co-evaporated with toluene (3×100 mL) and dried under high vacuum. To the residue was added 4-Iodo-benzoic acid ethyl ester (2.40 g) and co-evaporated with toluene (2×20 mL). Copper iodide (0.829 g) and DMF (10 mL) were added and reaction mixture heated at 95° C. for 18 hours, protected from light. To the cooled reaction mixture was added 3N ammonium hydroxide and extracted with dichloromethane (4×). Organic layer was dried (MgSO4), concentrated and purified by flash column chromatography (silica gel, 0 to 5% methanol/dichloromethane+1% triethylamine) to give 1-(4-Ethoxycarbonyl-phenyl)-2-oxo-1,2-dihydro-pyridine-4-carboxylic acid (1.155 g) as the triethylammonium salt: LCMS-ESI−: calc'd for C15H12NO5: 286.27 (M−H+). Found: 286.1 (M−H+).

출처