반응 #1587

반응 방정식

3-(4-chlorobenzoyl)propionic acid

hydrazine monohydrate

→

6-(4-chlorophenyl)-4,5-dihydropyridazinone

수율 80.0%

용매

ethanol

반응 조건

후처리

1. 1
   기타A thick solid was formed which
2. 2
   workup.DISSOLUTIONdissolved
3. 3
   온도after heating
4. 4
   온도The resulting solution was refluxed for 3 h
5. 5
   온도cooled
6. 6
   기타the solid formed
7. 7
   여과filtered
8. 8
   기타dried

실험 절차

To a solution of 3-(4-chlorobenzoyl)propionic acid (20g) in absolute ethanol (200 ml) was added 5 g of hydrazine monohydrate. A thick solid was formed which dissolved after heating. The resulting solution was refluxed for 3 h, cooled and the solid formed filtered and dried to yield 16 g (80%) of 6-(4-chlorophenyl)-4,5-dihydropyridazinone.

출처