반응 #1585794

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propane-1,3-diamine

6-bromo-3-iodo-8-(methylsulfonyl)imidazo[1,2-a]pyrazine

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title compound

수율 77.0%

N-(6-bromo-3-iodoimidazo[1,2-a]pyrazin-8-yl)propane-1,3-diamine

수율 77.0%

용매

N,N-dimethylformamide

N,N-dimethylformamide

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후처리

1. 1
   기타was prepared
2. 2
   기타The solvent was removed
3. 3
   기타the residue was purified by chromatography

실험 절차

To a solution of 1.26 mL propane-1,3-diamine in 8 mL 2.0 g N,N-dimethylformamide was added a solution of (4.98 mmol) 6-bromo-3-iodo-8-(methylsulfonyl)imidazo[1,2-a]pyrazine which was prepared according to intermediate example 60c in 20 mL N,N-dimethylformamide at 40° C. during 1.5 hours. The mixture was stirred at 40° C. for additional 1.5 hours. The solvent was removed and the residue was purified by chromatography to give 1.52 g (77%) of the title compound.

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