반응 #1585790

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6-bromo-3-iodo-8-methanesulfonyl-imidazo[1,2-a]pyrazine

isobutylamine

water

→

title compound

수율 78.0%

(6-bromo-3-iodo-imidazo[1,2-a]pyrazin-8-yl)-isobutyl-amine

수율 78.0%

용매

1-methylpyrrolidin-2-one

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후처리

1. 1
   추출the mixture was extracted with ethyl acetate
2. 2
   여과The organic phase was filtered
3. 3
   기타evaporated
4. 4
   기타the residue was recrystallized from methanol/water

실험 절차

To a stirred solution of 5.08 g (12.64 mmol) 6-bromo-3-iodo-8-methanesulfonyl-imidazo[1,2-a]pyrazine which was prepared according to intermediate example 1c in 100 mL 1-methylpyrrolidin-2-one were added 3.77 mL isobutylamine. After stirring at 23° C. for 2 hours, 500 mL water were added and the mixture was extracted with ethyl acetate. The organic phase was filtered, evaporated and the residue was recrystallized from methanol/water to yield 3.87 g (78%) of the title compound.

출처