반응 #158579

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N2,N4-bis(3-hydroxyphenyl)-5-fluoro-2,4-pyrimidinediamine

2,4-dichloro-5-fluoropyrimidine

4-isopropoxyaniline

→

5-fluoro-2,4-pyrimidinediamine

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후처리

1. 1
   기타were reacted

실험 절차

In a manner similar to the preparation of N2,N4-bis(3-hydroxyphenyl)-5-fluoro-2,4-pyrimidinediamine, 2,4-dichloro-5-fluoropyrimidine and 4-isopropoxyaniline were reacted to yield N2,N4-bis(4-isopropoxy)phenyl)-5-fluoro-2,4-pyrimidinediamine. 1H NMR (CDCl3): δ 7.89 (bs, 1H), 7.47 (d, 2H, J=8.7 Hz), 7.38 (d, 2H, J=9.0 Hz), 6.87 (d, 2H, J=9.0 Hz), 6.83 (d, 2H, J=8.7 Hz); LCMS: ret. time: 27.51 min.; purity: 98%; MS (m/e): 397 (MH+).

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